WHAT IS HOCl?
HOCl is an organic, naturally-occurring part of our internal defense system, and is produced in our white blood cells (neutrophils & macrophages). HOCl is a highly effective biocidal agent.
(Electrochemically activated solutions: evidence for antimicrobial efficacy and applications in healthcare environments. Thorn RM1, Lee SW, Robinson GM, Greenman J, Reynolds DM. Eur J Clin Microbiol Infect Dis. 2012 May;31(5):641-53.)
HOCl innately works to:
HOCl & Anti-Microbial Activity
When manufactured, HOCl is a well-known antimicrobial & biocidal that inactivates pathogens: Bacteria, Viruses, Spores, Fungi...
HOCl is safe for use on humans, and it’s proven benefits and varied applications are well-known in the world of science.
When applied topically, there is no bubbling or tingling, unlike other solutions that sting, irritate & aggravate tissue, causing further damage to the wound. Healthy granulation is protected!
HOCl consistently shows no adverse effects, only a steady control over the healing process that quickly becomes evident.
Brio HOCl™ Even Inactivates Prions!
*** In 2016, Dr. Jeffrey Williams and founder Dan Terry published an article in PLOS Pathogens that details a consistent 1-millionfold (8-Log Kill) inactivation of all PRION species by BRIOHOCl, per Rocky Mountain Lab’s, the lab that the National Institute of Health (NIH) uses for their testing measures.
***(PLOS Pathogens, 2016: Inactivation of Prions and Amyloid seeds with Hypochlorous Acid.)This is significant, as nothing has been proven to inactivate prions, including all widely accepted methods of disinfection (NaOH, UV, low-level incineration, autoclaving, boiling in bleach, etc.)
When an antigen is present locally, it’s gobbled up (phagocytized) by a neutrophil and/or macrophage (White Blood Cells.) HOCl is produced on-demand via an “Oxidative Burst” inside the White Blood Cell, and immediately inactivates - pathogens on contact.
HOCl - A KNOWN ANTI-INFLAMMATORY
Once an antigen is inactivated, HOCl quickly breaks down into saline and taurine chloramine (TauCl), a primary inflammation modulator. HOCl modulates inflammation through the effects on Nuclear Factor -kB to reduce epidermal pathology. Furthermore, HOCl neutralizes various proinflammatory cytokines and chemokines (chemotactic factors, leukotrienes, TNF-α, IL-1β, IL-2, and IL-6), regulates metalloproteinases, and releases activated growth factors. (Mainnemare A, Megarbane B, Soueidan A, Daniel A, Chapple, IL. Hypochlorous acid and taurine-N-monochloramine in periodontal diseases. J Dent Res 2004;83:823−31)
HOCl - AN IMMUNOLOGIC EFFECTOR
HOCl makes inert metabolic endotoxins and exotoxins produced by pathogenic metabolism, which are responsible for most tissue damage. HOCl further plays a key role is REDUCING TISSUE DAMAGE by regulating proteolytic activity during inflammation! (Hypochlorous Acid Generated by Neutrophils Inactivates ADAMTS13, AN OXIDATIVE MECHANISM FOR REGULATING ADAMTS13 PROTEOLYTIC ACTIVITY DURING INFLAMMATIONJ Biol Chem. 2015 Jan 16; 290(3): 1422–1431 - Yi Wang, et al.) HOCl stimulates T-cells to react more effectively to pathogens. (Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity Zofia M. Prokopowicz, Frederick Arce, Rafal Biedron, Cheryl, L.-L. Chiang, Marta Ciszek, David R. Katz, Maria Nowakowska, Szczepan Zapotoczny, Janusz Marcinkiewicz and Benjamin M. Chain -J Immunol January 15, 2010, 184 (2) 824-835)
HOCl - PROMOTES HEALING
HOCl induces the production of many cellular growth factors. (insulin-like growth factor, epidermal growth factor, keratinocyte growth factor (also called FGF-7), FGF-1, FGF-2, TGF-β, PDGF, vascular endothelium growth factor, connective tissue growth factor, and/or cementum-derived growth factor) - Grzesik WJ, Narayanan AS. Cementum and periodontal wound healing and regeneration. Crit Rev Oral Biol Med 2002;13:474−84.)
HOCl Modulates tissue collagenase enzymes, reorganizing scar fibers and softening existing fibrous tissue. HOCl Stimulates the Migration of Keratinocytes to the wound bed, promoting re-epithelialization. HOCl alters several key clotting components of human blood to increase local clot formation, while inhibiting dissolution of the clot.The Necrotizing Fasciitis Foundation recognizes HOCl as the best agent on the market to stop NF dead in its tracks!
BRIOTECH HOCL & BIOFILM ELIMINATION
Briotech HOCL annihilates biofilm. (Briotech Technology Brief on Applications - Briotech HOCl and Biofilm, Dr. Jeffrey F. Williams). The pure, stable and potent product that is Briotech HOCL, is a small molecule that readily penetrates deeply into the slime layers using the water channels. Briotech HOCL’s antimicrobial action degrades the adherent microbial populations, freeing the surface of slime and colonizing masses in a way unmatched by conventional disinfecting measures.
HOCl — THE “MIRACLE MOLECULE”
Science has known about the antimicrobial efficacy and disinfection properties of HOCl for over 100 years! There are even hundreds of WOUND CARE SPECIFIC studies that prove its efficacy! Stabilized HOCl’s Effect on Bioburden & Infection in Wound Healing (Journal of Burns & Wounds. 2007; 6: e6. Hypochlorous Acid as a Potential Wound Care Agent Part II. Stabilized Hypochlorous Acid: Its Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing Martin C. Robson, MD, et al.) HOCl Speeds Healing of Venous Leg Ulcers (The Symposium on Advanced Wound Care (SAWC), Dallas, TX, April 2011 Hypochlorous Acid Enabled Soft Debridement Speeds Healing of Refractory Venous Leg Ulcers - simplicity, low cost and patient comfort are advantages. Martin Winkler, MD, FACS) Stabilized HOCl is a Speedy, Ideal Wound Care Agent (Journal of Wounds. 2014 Dec;26(12):342-50. Hypochlorous Acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Sakarya S
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